Learn About Simvastatin 40 mg Side Effects

Simvastatin 40 mg Side EffectsThe statins class includes quite a few drugs with more or less similar action and side effects. Simvastatin is a drug part of this class, and it’s usually prescribed by the majority of physicians to patients with elevated levels of cholesterol. Indirectly, simvastatin can be used for the prevention of heart disease, or to reduce the incidence of cardiovascular problems.

In general, not only simvastatin but most statins should be used only after other cholesterol lowering methods have been tried by the patient but failed. In other words, an exercising and dieting program should be tried by a patient before starting medication with simvastatin.

Simvastatin is usually prescribed in 5 types of dosage: 5 mg, 10mg, 20 mg, 40 mg and 80 mg. Higher doses, over 160 mg, have a high degree of toxicity, leading to some of the most dangerous simvastatin side effects.

The most preferred dosage for simvastatin in patients with medium dyslipidaemia (increased amount of lipids in the blood) is 40 mg. Therefore, in this post I’m going to focus on the simvastatin 40 mg side effects.

The incidence of simvastatin 40 mg side effects is quite low, patients taking this daily dose of simvastatin can still experience side effects of gastrointestinal nature, like nausea, indigestion, diarrhea, or a general feeling of weakness. Although it’s not likely for the usual patient on medication with 40 mg of simvastatin to experience some of the more dangerous side effects of simvastatin, there’s still a low chance for these to occur. And these side effects are myopathy (muscular disease in which the muscle fibers don’t function properly, one of the main symptoms being muscular weakness), or in the worst cases, muscle injury and rhabdomyolysis. In general, if a patient develops muscle pains during medication with this drug, the cessation of the treatment is recommended.

There was an update by the Food and Drug Administration in March 2012 regarding the simvastatin side effects. The update came to add a few other side effects of this drug to the known ones. New tests revealed cases of increased blood sugar, a small increased risk for the development of type 2 diabetes, and in very rare cases, liver damage and memory loss. However, the last two are usually associated with higher dosage of the drug.

Although the incidence of simvastatin 40 mg side effects is rather low, myopathy and even rhabdomyolysis can occur if simvastatin is paired with drugs that hinder its metabolization. These are: nefazodone, erythromycin, itraconazole, clarithromycin, telithromycin, HIV protease inhibitors, ketoconazole. To avoid simvastatin 40 mg side effects especially diltiazem should not be administered. Also, it’s known that grapefruit juice may block or slow the metabolization of simvastatin and a patient should not drink it if under medication with simvastatin.

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