Lansoprazole Side Effects

What Is Lansoprazole

lansoprazole side effectsLansoprazole is a drug from the proton-pump inhibitors (PPI) class, used to reduce the production of gastric acids. It is indicated for the treatment of duodenal and stomach ulcers, the acid reflux disease (inflammation of the esophagus due to the repeated stomach acids coming up from the stomach), Zollinger-Ellison Syndrome (ulceration of the duodenum and stomach due to the hyper production of gastric acids).

Lansoprazole is also recommended as an adjunctive medication for infections with Heliobacter pylori. In cases like this, lansoprazole is administered along with clarithromycin and amoxicillin.

The Side Effects of Lansoprazole

In general, just like most other proton-pump inhibitors, lansoprazole is well tolerated, and the occurrence of side effects is rather low. However, some of the common lansoprazole side effects can be: nausea, headaches, dizziness, drowsiness, blurred vision, dry mouth, diarrhea. One of the less common specific lansoprazole side effects is taste disturbance.

Other rare lansoprazole side effects can be: fever, peripheral oedema, hyperhidrosis (excessive sweating), depression, joint pain, muscle pain, liver dysfunction, various blood disorders, photosensitivity, (leukocytosis, thrombocytopenia, pancytopenia or leukopenia).

In very rare cases, skin reactions have been reported as photon-pump inhibitors adverse effects and also as lansoprazole side effects. These are: toxic epidermal necrolysis, Stevens-Johnson syndrome, erythroderma.

Hypersensitivity to the drug may induce various lansoprazole side effects of allergic nature. These are: rash, skin itchiness, angioedema, bronchospasm, or even anaphylaxis.

Lansoprazole Interactions And Contraindications

Proton-pump inhibitors (PPI) in general, reduce the absorption process of antifungal drugs. Also, it may increase the plasma concentrations of Digoxin and Cilostazol, increasing the risks of toxicity, therefore it should not be administered along with these drugs. Lansoprazole can also interact (generally slowing the absorption) with other drugs like ampicillin, clopidogrel, warfarin, voriconazole, astemizole, aminophylline, theophylline, fluvoxamine, sucralfate, bisacodyl.

Since lansoprazole reduces the absorption if iron salts, it’s not recommended in case of anemia. Also, since one of the rare lansoprazole side effects is liver dysfunction, it’s not recommended to patients with a history of liver disease.

PPI drugs reduce gastric acids, so obviously aren’t recommended in case of indigestion.

In case of pregnancy or nursing lensopazole is not recommended.

Lansoprazole Dosage and Administration

Lansoprazole is not recommended to children, and its administration to elderly people requires special dosage.

It’s recommended to take this drug just as your doctor recommended, but in general, the dosage for various conditions is as it follows:

– For acid reflux disease: 30 mg of lansoprazole, once per day;
– For duodenal ulcer: 30 mg of lansoprazole once a day;
– For dyspepsia caused by gastric hyperacidity: 15 mg of lansoprazole, once per day;
– For H. pylori: 30 mg of lansoprazole administered in conjunction with clarithromycin and amoxicillin, usually twice per day;

Each dose should be taken one hour or at least 30 minutes before a meal. Taken along with food, the absorption process of lansoprazole is slowed.

In general, to benefit the most from treatment with lansoprazole, it’s best to reduce or quit smoking if you’re a smoker, because smoking increase stomach acidity. Also, reducing the alcohol consumption, and avoiding foods and drinks with high acidity, like citrus fruits or citrus juices, spicy foods, tomatoes, will help you a lot with any of the conditions this drug was prescribed for.

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