Diclofenac And The Side Effects

diclofenac side effectsDiclofenac is an anti-inflammatory drug, also used as a pain killer for certain conditions. This drug can also be supplied as a potassium or sodium salt. Although it’s commonly commercialized as tablets, diclofenac can also be found as gel, for external use in cases actinic keratosis and various musculoskeletal conditions.

Diclofenac is, in general, recommended for various types of arthritis, ankylosing spondylitis, dermatomyositis, polymyositis. As a pain management drug it is usually prescribed to alleviate gout attacks, for gallstones and kidney stones related pain, dysmenorrhea and dental pain.

Diclofenac is also used as an analgesic for post-traumatic or post-operative pain, especially when inflammation is present.

Recent studies have shown that diclofenac is really effective against drug-resistant Escherichia coli strains, and can be recommended for treatment of mild urinary infections with E. coli.

Gastrointestinal problems are the most commonly reported diclofenac side effects. These usually are: nausea, vomiting, stomach pain, diarrhea, gas. Diclofenac can also induce ulceration of the stomach tissue that’s why it is sometimes administered in conjunction with various ulcer-protective drugs. However, in case of stomach bleeding, immediate cessation of the diclofenac treatment is required.

In case of suppository treatment with diclofenac, side effects may include a local burning sensation, itching and sometimes diarrhea.

Most of the non-steroidal anti-inflammatory drugs are known to increase the risk of heart attack or heart problems. Diclofenac does not make an exception. However, the risk of a heart attack as one of the diclofenac side effects is very small. In patients with diabetes mellitus, diclofenac treatment can cause an increase of the blood pressure.

Liver damage or liver problems are also listed as diclofenac side effects, but these also occur rarely. According to various studies, diclofenac wasn’t found more hepatotoxic than other non-steroidal anti-inflammatory drugs. And in general, diclofenac side effects on the liver occur in cases of long-term treatment with the drug.

A series of studies have shown that diclofenac caused acute renal failure on vultures after they have consumed the carcasses of other animals recently treated with the drug. Therefore, this drug should not be administered to people with a history of renal disease, or renal insufficiency.

Other infrequent diclofenac side effects are: bone marrow depression, disturbance of the menstrual cycle, anxiety, depression, nightmares and psychotic reactions.

Of course, allergic reactions to the drug can be urticaria, bronchospasm, anaphylaxis.

Due to its important gastrointestinal impact, diclofenac is not recommended to patients with digestive tract problems, especially to patients with active ulceration of inflammatory intestinal disorders like Crohn’s disease.

It’s not recommended to people with severe heart insufficiency, or hepatic and renal insufficiency. Although this drug is recommended for post-operative inflammation, medication with diclofenac post heart surgery shouldn’t be administered.

Diclofenac is also contraindicated in case of dengue fever because it may cause acute capillary leakage and may lead to heart failure.

Diclofenac increases the lithium and digoxin levels which may lead to toxicity. It may also diminish the effect of antihypertensive medication.

Leave a Comment