The Co-Codamol Side Effects

co codamol side effectsCo-codamol is a combination of paracetamol (acetaminophen) and codeine phosphate, used as an analgesic, for mild or moderate pain. There are various types of co-codamol, given by the concentration of codeine they contain. In general, the most common formulations of co-codamol contain 300 mg of paracetamol, however, the contents of paracetamol may vary from 300 mg to 1000 mg.

There are 4 most common strengths of co-codamol. They are called Tylenols, and they are:

Tylenol 1 – 8 mg codeine / 325 mg paracetamol

Tylenol 2 – 15 mg codeine / 300 mg paracetamol

Tylenol 3 – 30 mg codeine / 300 mg paracetamol

Tylenol 4 – 60 mg codeine / 300 mg paracetamol.

From a country to another, there are different variations of this drug. For example, in Canada Tylenol 1, 2 and 3 are enriched with 15 mg of caffeine to alleviate nausea. Co-codamols are commercialized under different brand names all over the world (Atasol Codeine, Paralgin, Panadeine, Pinex, Solpadeine etc). In some countries, some or even all of the variations of co-codamol are available over-the-counter.

One of the co-codamol side effects that should be head of the list is addiction. Like many other analgesic drugs, co-codamols are addictive drugs, and medication (especially long-term medication) with them isn’t recommended to people who have a history with drug abuse.

Most of the others co-codamol side effects are of mild nature. Patients that take co-codamols may commonly experience the following adverse effects: nausea, gastrointestinal problems (constipation, vomiting, stomach pain), drowsiness, dizziness, changes in the blood, gums or nose bleeds, easy bruising, dry mouth and thirst.

In rare cases some patients may experience euphoria (intense feeling of well-being and happiness) or the opposite, dysphoria (intense depression, mood disorders and even suicidal behavior), as co-codamol side effects.

In general, the co-codamol side effects can include the side effects that a patient may experience due to the intake of codeine or paracetamol. Along with the ones mentioned above, co-codamol side effects given by the codeine may also be urinary retention, miosis, orthostatic hypotention, and paradoxically coughing.

Other co-codamol side effects given by the paracetamol may be sweating and pallor (pale color of the skin given by the reduced amount of oxyhemoglobin).

Patients can also develop allergic reactions to co-codamol, and some of the adverse effects of allergic nature are skin itchiness and rashes, difficulties breathing or even anaphylactic shock.

To avoid overdosage, and the overdosage associated co-codamol side effects which may have a serious negative effect to your health, this drug should not be taken in conjunction with other drugs containing paracetamol. The maximum 24 hours dose of paracetamol should never exceed 8×500 mg or paracetamol, to avoid toxicity.

Co-codamol should not be taken with alcohol and it’s not recommended to alcohol user due to increased risks of toxicity.

Fasting is also not recommended during medication with co-codamol or paracetamol due to the depleted hepatic glutathione reserves, which may lead to hepatotoxicity. Also, high doses of paracetamol in conjunction with a lot of caffeine can lead to liver damage.

Althoug paracetamol is considered a safe drug for pregnancy and nursing, codeine which is also contained by co-codamols, passes into the milk and can cause respiratory depression to the breastfed infant.

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